A case of guillain-barre syndrome in a patient with non small cell lung cancer treated with chemotherapy

Nicolo' Gebbia, Giuseppe Badalamenti, Giuseppe Cicero, Fabio Fulfaro, Nicola Gebbia, Caraceni, Carmelo Carlo Arcara, Chiara Intrivici

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5 Citations (Scopus)

Abstract

Guillain-Barré Syndrome (GBS) is a demyelinating polyneuropathy of probable autoimmune pathogenesis characterized by rapidly progressive symmetric paralysis. In the literature some cases of GBS associated with anticancer chemotherapy are reported. We present a case of a 55-year old woman who complained of progressive motor deficit in four limbs, areflexia in lower limbs and facial nerve paralysis one week after beginning cisplatin-gemcitabine chemotherapy for metastatic lung cancer. The cerebrospinal fluid analysis showed a strong positive Pandy reaction with 435 mg/dl total protein. The electromyography and the electroneuronography established the diagnosis of inflammatory demyelinating polyneuropathy. Specific therapy with intravenous immunoglobulin 25 g/day in 5 administrations for 5 days was started with complete benefit.
Original languageEnglish
Pages (from-to)325-327
Number of pages3
JournalJournal of Chemotherapy
Volume18
Publication statusPublished - 2006

All Science Journal Classification (ASJC) codes

  • Oncology
  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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