A Case of Cardiomyopathy Due to Premature Ductus Arteriosus Closure: The Flip Side of Paracetamol

Ettore Piro, Mario Giuffre, Giovanni Corsello, Ingrid Anne Mandy Schierz, Simona La Placa

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Paracetamol (acetaminophen or N-acetyl-p-aminophenol) is considered a safe analgesic and antipyretic nonsteroidal antiinflammatory drug commonly used during pediatric ages and during pregnancy. We report on a term neonate with closed ductus arteriosus, severe cardiomyopathy, right ventricular dysfunction, and functional stenosis of pulmonary arteries at birth after maternal self-medication with paracetamol and consumption of polyphenol-rich foods in late pregnancy. This drug, especially when associated with other vasoconstrictors (such as polyphenols), interferes with prostaglandin metabolism, which seriously accentuates the intrauterine ductus arteriosus constriction and leads to pharmacologic adverse events. We suggest maternal educational programs to avoid risky self-medications and provide training for the best diets.
Original languageEnglish
Number of pages5
JournalPediatrics
Volume141
Publication statusPublished - 2018

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health

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