3D-Printed Solid Dispersion Drug Products

Laura Modica De Mohac, Bahijja Tolulope Raimi-Abraham, Laura Modica De Mohac, Suet Li Chew

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

With the well-known advantages of additive manufacturing methods such as three-dimensional (3D) printing in drug delivery, it is disappointing that only one product has been successful in achieving regulatory approval in the past few years. Further research and development is required in this area to introduce more 3D printed products into the market. Our study investigates the potential of fixed dose combination solid dispersion drug products generated via 3D printing. Two model drugs—fluorescein sodium (FS) and 5-aminosalicyclic acid (5-ASA)—were impregnated onto a polyvinyl alcohol (PVA) filament, and the influence of solvent choice in optimal drug loading as well as other influences such as the physicochemical and mechanical properties of the resultant filaments were investigated prior to development of the resultant drug products. Key outcomes of this work included the improvement of filament drug loading by one- to threefold due to solvent choice on the basis of its polarity and the generation of a 3D-printed product confirmed to be a solid dispersion fixed dose combination with the two model drugs exhibiting favourable in vitro dissolution characteristics
Original languageEnglish
Number of pages12
JournalPharmaceutics
Publication statusPublished - 2019

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

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