25-Hydroxyvitamin D, IL-31, and IL-33 in Children with Allergic Disease of the Airways

Stefania La Grutta, Velia Malizia, Paolo Colombo, Fabio Cibella, Loredana Riccobono, Mirella Profita, Stefania La Grutta, Sebastiano Gangemi, Anna Bonanno

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    37 Citations (Scopus)


    Low vitamin D is involved in allergic asthma and rhinitis. IL-31 and IL-33 correlate with Th2-associated cytokines in allergic disease. We investigated whether low vitamin D is linked with circulating IL-31 and IL-33 in children with allergic disease of the airways. 25-Hydroxyvitamin D [25(OH) Vit D], IL-31, and IL-33 plasma levels were measured in 28 controls (HC), 11 allergic rhinitis (AR) patients, and 35 allergic asthma with rhinitis (AAR) patients. We found significant lower levels of 25(OH) Vit D in AR and in AAR than in HC. IL-31 and IL-33 plasma levels significantly increased in AAR than HC. IL-31 and IL-33 positively correlated in AR and AAR. 25(OH) Vit D deficient AAR had higher levels of blood eosinophils, exacerbations, disease duration, and total IgE than patients with insufficient or sufficient 25(OH) Vit D. In AAR 25(OH) Vit D levels inversely correlated with total allergen sIgE score and total atopy index. IL-31 and IL-33 did not correlate with 25(OH) Vit D in AR and AAR. In conclusion, low levels of 25(OH) Vit D might represent a risk factor for the development of concomitant asthma and rhinitis in children with allergic disease of the airways independently of IL-31/IL-33 Th2 activity
    Original languageEnglish
    Pages (from-to)1-10
    Number of pages10
    JournalMediators of Inflammation
    Publication statusPublished - 2014

    All Science Journal Classification (ASJC) codes

    • Immunology
    • Cell Biology


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