1,3,5-Triazines: A promising scaffold for anticancer drugs development

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46 Citations (Scopus)

Abstract

This review covering literature reports from the beginning of this century to 2016 describes the synthetic pathways, the antitumor activity, the structure-activity relationship and, whenever reported, the possible mechanism of action of 1,3,5-triazine derivatives as well as of their hetero-fused compounds. Many 1,3,5-triazine derivatives, both uncondensed and hetero-fused, have shown remarkable antitumor activities and some of them reached clinical development.
Original languageEnglish
Pages (from-to)523-549
Number of pages27
JournalEuropean Journal of Medicinal Chemistry
Volume142
Publication statusPublished - 2017

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery
  • Organic Chemistry

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