γδ cells and tumor microenvironment: A helpful or a dangerous liason?

Elena Lo Presti, Gabriele Pizzolato, Francesco Dieli, Serena Meraviglia, Filippo Mocciaro, Roberto Di Mitri, Filippo Mocciaro, Roberto Di Mitri

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

gamma delta T cells are a subset of T lymphocytes that have been implicated in immunosurveillance against infections and tumors. T cells are endowed with antitumor activities, and hence several T cell-based small-scale clinical trials have been conducted either by in vivo activation by intravenous administration of aminobiphosphonates or by adoptive transfer of invitro expanded T cells. Although both these strategies have yielded promising results, there are a number of limitations associated with each of them which, if overcome may help to further improve efficacy. One of the most important limits is the possible polarization of tumor-infiltrating T cells toward different T cells population with functional activities that help the progression and spread of the tumor. Here, we review the modalities and the possible mechanisms involved in the polarization of tumor-infiltrating T cells upon interaction with several components of the tumor microenvironment and discuss their implications for the manipulation of T cells in cancer immunotherapy.
Original languageEnglish
Pages (from-to)485-492
Number of pages8
JournalJournal of Leukocyte Biology
Volume103
Publication statusPublished - 2018

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Cell Biology

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