β-Thalassemia heterozygote state detrimentally affects health expectation

Massimo Attanasio, Salvatore Scondotto, Angela Vitrano, Rosario Di Maggio, Massimiliano Sacco, Gabriella Dardanoni, Luciano Graffeo, Walter Sebastiano Pollina Addario, Disma Renda, Antonino Giambona, Christian Gluud, Aurelio Maggio, Rosario Di Maggio

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Background: Thalassemia minor (Tm) individuals, are generally considered healthy. However, the prognosis of Tm individuals has not been extensively studied. The aim of this study was to evaluate the prognosis of Tm versus controls without β-thalassemia carrier state. Methods: A total of 26,006 individuals seeking thalassemia screening at the AOOR Villa Sofia-V. Cervello, Palermo (Italy) were retrospectively studied. Logistic penalised regression model was used to estimate risk of potential complications and survival techniques were used to study mortality. Results: We identified a total of 4943 Tm and 21,063 controls. Tm was associated with significantly higher risks of hospitalisation for cirrhosis (OR 1·94, 95% CI 1·30 to 2·90, p = 0·001), kidney disorders (OR 2·11, 95% CI 1·27 to 3·51, p = 0·004), cholelithiatis (OR 1·39, 95% CI 1·08 to 1·79, p = 0·010), and mood disorders (OR 2·08, 95% CI 1·15 to 3·75, p = 0·015). No statistically difference in life expectancy between thalassemia minor and control group was found (HR 1·090, 95% CI 0·777 to 1·555, p < 0·590; log-rank test p =.426). Conclusion: This study shows that Tm affects the prognosis of Tm carriers regarding health expectation. Probably, iron overload and anaemia for several years may be at the basis of these effects.
Original languageEnglish
Pages (from-to)76-80
Number of pages5
JournalEuropean Journal of Internal Medicine
Volume54
Publication statusPublished - 2018

All Science Journal Classification (ASJC) codes

  • Internal Medicine

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